Vaccine Production to Protect Animals Against Pathogenic Clostridia.
Identifieur interne : 000642 ( Main/Exploration ); précédent : 000641; suivant : 000643Vaccine Production to Protect Animals Against Pathogenic Clostridia.
Auteurs : Nicolas E. Zaragoza [Australie] ; Camila A. Orellana [Australie] ; Glenn A. Moonen [Australie] ; George Moutafis [Australie] ; Esteban Marcellin [Australie]Source :
- Toxins [ 2072-6651 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
- prévention et contrôle : Infections à Clostridium.
- usage thérapeutique : Vaccins antibactériens.
- Animaux, Clostridium, Humains, Toxines bactériennes.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Bacterial Vaccines.
- chemical : Bacterial Toxins.
- prevention & control : Clostridium Infections.
- Animals, Clostridium, Humans.
Abstract
Clostridium is a broad genus of anaerobic, spore-forming, rod-shaped, Gram-positive bacteria that can be found in different environments all around the world. The genus includes human and animal pathogens that produce potent exotoxins that cause rapid and potentially fatal diseases responsible for countless human casualties and billion-dollar annual loss to the agricultural sector. Diseases include botulism, tetanus, enterotoxemia, gas gangrene, necrotic enteritis, pseudomembranous colitis, blackleg, and black disease, which are caused by pathogenic Clostridium. Due to their ability to sporulate, they cannot be eradicated from the environment. As such, immunization with toxoid or bacterin-toxoid vaccines is the only protective method against infection. Toxins recovered from Clostridium cultures are inactivated to form toxoids, which are then formulated into multivalent vaccines. This review discusses the toxins, diseases, and toxoid production processes of the most common pathogenic Clostridium species, including Clostridiumbotulinum, Clostridiumtetani, Clostridiumperfringens, Clostridiumchauvoei, Clostridiumsepticum, Clostridiumnovyi and Clostridiumhemolyticum.
DOI: 10.3390/toxins11090525
PubMed: 31514424
PubMed Central: PMC6783934
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Zaragoza</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072</wicri:regionArea><wicri:noRegion>QLD 4072</wicri:noRegion></affiliation></author><author><name sortKey="Orellana, Camila A" sort="Orellana, Camila A" uniqKey="Orellana C" first="Camila A" last="Orellana">Camila A. Orellana</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072</wicri:regionArea><wicri:noRegion>QLD 4072</wicri:noRegion></affiliation></author><author><name sortKey="Moonen, Glenn A" sort="Moonen, Glenn A" uniqKey="Moonen G" first="Glenn A" last="Moonen">Glenn A. Moonen</name><affiliation wicri:level="1"><nlm:affiliation>Zoetis, 45 Poplar Road, Parkville VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Zoetis, 45 Poplar Road, Parkville VIC 3052</wicri:regionArea><wicri:noRegion>Parkville VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="Moutafis, George" sort="Moutafis, George" uniqKey="Moutafis G" first="George" last="Moutafis">George Moutafis</name><affiliation wicri:level="1"><nlm:affiliation>Zoetis, 45 Poplar Road, Parkville VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Zoetis, 45 Poplar Road, Parkville VIC 3052</wicri:regionArea><wicri:noRegion>Parkville VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="Marcellin, Esteban" sort="Marcellin, Esteban" uniqKey="Marcellin E" first="Esteban" last="Marcellin">Esteban Marcellin</name><affiliation wicri:level="1"><nlm:affiliation>Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia. e.marcellin@uq.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072</wicri:regionArea><wicri:noRegion>QLD 4072</wicri:noRegion></affiliation></author></analytic><series><title level="j">Toxins</title><idno type="eISSN">2072-6651</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Bacterial Toxins (MeSH)</term><term>Bacterial Vaccines (therapeutic use)</term><term>Clostridium (MeSH)</term><term>Clostridium Infections (prevention & control)</term><term>Humans (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Clostridium (MeSH)</term><term>Humains (MeSH)</term><term>Infections à Clostridium (prévention et contrôle)</term><term>Toxines bactériennes (MeSH)</term><term>Vaccins antibactériens (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Bacterial Vaccines</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Bacterial Toxins</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Clostridium Infections</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Infections à Clostridium</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins antibactériens</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Clostridium</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Clostridium</term><term>Humains</term><term>Toxines bactériennes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><i>Clostridium</i> is a broad genus of anaerobic, spore-forming, rod-shaped, Gram-positive bacteria that can be found in different environments all around the world. The genus includes human and animal pathogens that produce potent exotoxins that cause rapid and potentially fatal diseases responsible for countless human casualties and billion-dollar annual loss to the agricultural sector. Diseases include botulism, tetanus, enterotoxemia, gas gangrene, necrotic enteritis, pseudomembranous colitis, blackleg, and black disease, which are caused by pathogenic <i>C</i><i>lostridium</i>. Due to their ability to sporulate, they cannot be eradicated from the environment. As such, immunization with toxoid or bacterin-toxoid vaccines is the only protective method against infection. Toxins recovered from <i>Clostridium</i> cultures are inactivated to form toxoids, which are then formulated into multivalent vaccines. This review discusses the toxins, diseases, and toxoid production processes of the most common pathogenic <i>C</i><i>lostridium</i> species, including <i>C</i><i>lostridium</i><i>botulinum</i>, <i>C</i><i>lostridium</i><i>tetani</i>, <i>C</i><i>lostridium</i><i>perfringens</i>, <i>C</i><i>lostridium</i><i>chauvoei</i>, <i>C</i><i>lostridium</i><i>septicum</i>, <i>C</i><i>lostridium</i><i>novyi</i> and <i>C</i><i>lostridium</i><i>hemolyticum</i><i>.</i></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31514424</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>02</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>02</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2072-6651</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>9</Issue><PubDate><Year>2019</Year><Month>09</Month><Day>11</Day></PubDate></JournalIssue><Title>Toxins</Title><ISOAbbreviation>Toxins (Basel)</ISOAbbreviation></Journal><ArticleTitle>Vaccine Production to Protect Animals Against Pathogenic Clostridia.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E525</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/toxins11090525</ELocationID><Abstract><AbstractText><i>Clostridium</i> is a broad genus of anaerobic, spore-forming, rod-shaped, Gram-positive bacteria that can be found in different environments all around the world. The genus includes human and animal pathogens that produce potent exotoxins that cause rapid and potentially fatal diseases responsible for countless human casualties and billion-dollar annual loss to the agricultural sector. Diseases include botulism, tetanus, enterotoxemia, gas gangrene, necrotic enteritis, pseudomembranous colitis, blackleg, and black disease, which are caused by pathogenic <i>C</i><i>lostridium</i>. Due to their ability to sporulate, they cannot be eradicated from the environment. As such, immunization with toxoid or bacterin-toxoid vaccines is the only protective method against infection. Toxins recovered from <i>Clostridium</i> cultures are inactivated to form toxoids, which are then formulated into multivalent vaccines. This review discusses the toxins, diseases, and toxoid production processes of the most common pathogenic <i>C</i><i>lostridium</i> species, including <i>C</i><i>lostridium</i><i>botulinum</i>, <i>C</i><i>lostridium</i><i>tetani</i>, <i>C</i><i>lostridium</i><i>perfringens</i>, <i>C</i><i>lostridium</i><i>chauvoei</i>, <i>C</i><i>lostridium</i><i>septicum</i>, <i>C</i><i>lostridium</i><i>novyi</i> and <i>C</i><i>lostridium</i><i>hemolyticum</i><i>.</i></AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zaragoza</LastName><ForeName>Nicolas E</ForeName><Initials>NE</Initials><AffiliationInfo><Affiliation>Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Orellana</LastName><ForeName>Camila A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moonen</LastName><ForeName>Glenn A</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>Zoetis, 45 Poplar Road, Parkville VIC 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moutafis</LastName><ForeName>George</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Zoetis, 45 Poplar Road, Parkville VIC 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marcellin</LastName><ForeName>Esteban</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia. e.marcellin@uq.edu.au.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>09</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Toxins (Basel)</MedlineTA><NlmUniqueID>101530765</NlmUniqueID><ISSNLinking>2072-6651</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001427">Bacterial Toxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001428">Bacterial Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001427" MajorTopicYN="N">Bacterial Toxins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001428" MajorTopicYN="N">Bacterial Vaccines</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003013" MajorTopicYN="Y">Clostridium</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003015" MajorTopicYN="N">Clostridium Infections</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Clostridium</Keyword><Keyword MajorTopicYN="Y">clostridia diseases</Keyword><Keyword MajorTopicYN="Y">fermentation</Keyword><Keyword MajorTopicYN="Y">toxoids</Keyword><Keyword MajorTopicYN="Y">vaccine production</Keyword></KeywordList><CoiStatement>Zoetis has interest in commercializing vaccines. 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Zaragoza</name></noRegion><name sortKey="Marcellin, Esteban" sort="Marcellin, Esteban" uniqKey="Marcellin E" first="Esteban" last="Marcellin">Esteban Marcellin</name><name sortKey="Moonen, Glenn A" sort="Moonen, Glenn A" uniqKey="Moonen G" first="Glenn A" last="Moonen">Glenn A. Moonen</name><name sortKey="Moutafis, George" sort="Moutafis, George" uniqKey="Moutafis G" first="George" last="Moutafis">George Moutafis</name><name sortKey="Orellana, Camila A" sort="Orellana, Camila A" uniqKey="Orellana C" first="Camila A" last="Orellana">Camila A. Orellana</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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